Fatal Flaws

Fatal Flaws

How A Misfolded Protein Baffled Scientists and Changed the Way We Look at the Brain

Book - 2013
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"Discovered and identified as the cause of mad cow disease only three decades ago, the prion is a protein molecule that, when misshapen in the brain, becomes fatal. Novel and controversial, prions have provoked a scientific revolution. They challenge the very foundations of biology: A disease-causing entity with no genetic material at all? A molecule capable of infecting, multiplying, and killing? This book recounts the birth of prion science and the imaginative detective work scientists have undertaken as they struggle to find the answers to devastating brain diseases from mad cow and Creutzfeld-Jakob disease to Parkinson's, Alzheimer's, Lou Gehrig's, and others. As in each of his best-selling books, Jay Ingram here makes complex scientific concepts accessible and shows how little-known events may have profound significance. He describes the development of prion science as a rough-and-tumble affair, with rivals, eccentrics, interfering governments, and brilliantly creative people all playing salient roles. Weaving biology, medicine, human tragedy, discovery, and bitter scientific competition into his account, he reveals the stunning potential of prion science, whose discoveries may unlock the answers to some of humankind's most destructive diseases"--Provided by publisher.
Publisher: New Haven : Yale University Press, 2013
ISBN: 9780300189896
Branch Call Number: 616.83 INGRAM
Characteristics: viii, 282 pages : illustrations ; 22 cm


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Donald W Mayfield
Sep 26, 2017

It is a good read and a companion to _Introduction to Protein Science_ by Arthur M. Lesk. I does in words what Lesk's book does in pictures, some in 3D.

Feb 20, 2014

I could not put this book down. loved it

Sep 27, 2012

It's true, you'll never look at hamburger with dewy-eyed innocence again. Good thing I love chicken, fish, beans, lamb, pork, etc. At least till the next horror hits.

Jul 19, 2012

A must read, you will never look at your hamburger in the same way. Jay Ingram provides a very good read on a complex subject even for a non scientist. The actions of the British government on the BSE episode is absolutely shameful. One wonders what our own government is hiding with the muzzle they have put on the Health Canada scientists.


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